Our Clients' Most Frequently Asked Questions

A microbiome is like a tiny but vast city of microscopic creatures living inside your body that help keep your body healthy and function.

If you think back to your high school biology class, you probably remember learning about cells. You learned that the human body is made up of many different kinds of cells — skin cells, muscle cells, neurons, and blood cells, for example. You might even remember learning that each of these different kinds of cells develops and functions in accordance with the directions encoded by a single set of genes shared by all human cells and that the full set of these human genes is called the human genome.

What you almost certainly did not hear about was that the human body also contains trillions of cells that are not human, but microbial, each of which has its own unique complement of genes. Together, these microbes constitute the human microbiome and scientists are now finding that they play an important role in human health. If you need a little refresher course on the definition of microbes, please take a look at the box entitled “Wait a minute! What’s a microbe?”

The bottom line is that the human body hosts a huge number of microbes of many different kinds. These microbes play a role in many fundamental life processes. The collection of microbes that constitute the microbiome is not random; the human microbiome is made up of a particular set of microbes that complement each other and the human host. Systematic study of the human microbiome is a very young science and scientists are just beginning to address the questions of what constitutes a normal microbiome, how the microbiome changes over time, and how the composition and activity of the microbiome affect health and disease. What is already clear is that the effect of the microbiome on its human host is profound and multifaceted. Indeed, it is reasonable to characterize the microbiome as a newly recognized organ, with a great range of metabolic activities.

Microbiomes are important because they’re like tiny helpers in your body. They are responsible for helping you digest food, fight off germs, and keep you healthy. They keep your body and mind in balance.

Imagine a bustling metropolis with a wide variety of residents who all cooperate to keep it running properly. Consider this metropolis as being inside of you right now. Welcome to your microbiome! The trillions of bacteria that make up our interior ecosystem are essential to maintaining our health. What happens, however, when pollutants from the environment enter this city? Let’s explore the impact of environmental contaminants on our microbiota and its hidden world.

The microbiome: What is it? The community of bacteria, viruses, fungi, and other microbes that live in and on human bodies is known as the microbiome. They aid in digestion, protect us from hazardous pathogens, and even have an impact on our mood. They are, in essence, our tiny allies. But the microbiome requires equilibrium, just like any city. Health issues can result when dangerous chemicals, such as environmental pollutants, upset this balance.

Environmental toxins are dangerous compounds that are found around us. Heavy metals like lead and mercury, agricultural pesticides, air pollution, and chemicals in the everyday items we use are just a few examples. These pollutants can harm our microbiome by infiltrating our bodies through air, food, water, or skin contact.

These poisons can alter the microbiome after they have entered our systems. They may cause a decrease in the number of helpful bacteria and an increase in hazardous ones. What occurs to our microbiota is like what would happen if troublemakers suddenly flooded into a previously tranquil city, causing havoc.

For instance, heavy metals can cause digestive problems by reducing the diversity of our gut microorganisms. Our gut microbiome can be upset by pesticides, which could lead to inflammation and weight gain. Our gut microbiota and the health of our lungs are both impacted by air pollution, which can result in respiratory and metabolic problems. Even the chemicals included in commonly used goods have the potential to affect our microbiome by interfering with our hormones.

Changes in our microbiome can lead to a domino effect on our health. From obesity and digestive problems to heart disease and even mental health diseases, an unbalanced microbiome, or dysbiosis, has been linked to several health problems. Our microbiome also greatly impacts how our immune systems work and how our bodies react to drugs. Therefore, a messed-up microbiome can have a variety of effects on our general health.

Environmental chemicals’ impacts on our microbiome seriously harm our health. We are exposed to these poisons as we go about our daily lives, which can destabilize our internal microbial city. But by comprehending this unseen danger, we may take precautions to safeguard our microbiota and therefore, our health.

To properly comprehend how these poisons could be potentially affecting our microbiome and our health, at Revolution Gut Health we offer comprehensive testing to analyze the presence and amounts of hundreds of different kinds of toxins commonly found in the environment and we specialize in customizing individualized protocols that help your body to detoxify improving dramatically the elimination of them from the body. Also, we help you take action to lessen our exposure to environmental poisons in the interim. This can involve consuming organic food, utilizing natural remedies, and supporting cleaner air policies. Do not forget that you are only as healthy as your microbiome!

We are exposed to multiple factors that can negatively affect our microbiome in the modern world. Here are some of the most common:

• Antibiotics
• Processed Foods
• Pollution
• Stress
• Toxins

Antibiotics are perhaps the most well-known factor that can damage gut microbiota. They work by killing bacteria, but they don’t discriminate between “good” and “bad” bacteria. This can lead to an imbalance in gut flora and potentially gut dysbiosis.

Processed foods are another common factor that can damage gut health. These foods are often high in sugar and unhealthy fats, feeding pathogenic bacteria and yeast. They also tend to be low in fiber, essential for gut health.

Pollution is a broad term that can refer to several different environmental toxins. These toxins can come from car exhaust, industrial waste, and even cleaning products, and they can damage gut health by causing inflammation and killing beneficial gut bacteria.

Stress is another factor that can negatively impact gut health. When we’re stressed, our bodies produce cortisol and other stress hormones, and these hormones can damage gut bacteria and lead to gut dysbiosis.

Toxins are another factor that can damage gut microbiota. Toxins can come from various sources, including food, water, and even the air we breathe, and they can cause inflammation and kill beneficial gut bacteria.

Avoiding all damaging factors to the microbiome is nearly impossible, but knowing how to identify them on time can significantly improve your and your microbiome’s health. When the gut microbiome is in balance, it helps to:

• Boost immunity
• Aid indigestion
• Reduce inflammation
• Detoxify the body
• Produce vitamins and other nutrients

If the gut microbiome is out of balance, it can lead to many health problems, including:

• Autoimmune diseases
• Digestive disorders
• Obesity
• Diabetes
• Allergies
• Anxiety and depression

At Revolution Gut Health, we are not only committed to bringing back your microbiome balance but also to teaching you how to protect it from all the things that can damage it over time. With our help, you can keep your gut microbiome healthy and balanced for years!

The microbial world may be largely invisible to the human eye, but it is vast, almost beyond imagination. There are hundreds of thousands of different kinds of bacteria alone (leaving aside for the moment the other kinds of microbes: archaea, viruses, fungi, and protists), living in every conceivable environment including deep under the seabed, high in the clouds, in the near boiling hot springs of Yellowstone National Park, and in highly acidic drainage from old mines.

Billions of years before multicellular organisms emerged, microbes had seemingly occupied every possible ecological niche. The emergence of multicellular organisms created an entirely new set of habitats — in and on all those animals and plants. The kinds of partnerships between animals and plants and their microbes are just beginning to be explored, but the important thing to recognize is that these associations are not random. Each organism has evolved to have intimate associations with particular kinds of microbes — perhaps not exactly the same species in every case, but with characteristic types. Humans are no exception; of the hundreds of thousands of kinds of microbes on Earth, only about 1,000 have been found associated with humans.

So there are hundreds of thousands of different kinds of microbes in the world, and several hundred different kinds are generally found in the average human microbiome. How do we get the right ones? Where do they come from?

The short answer is that we get most of them from other humans. Newborn babies encounter microbes for the first time during birth. As the baby is being born, it is coated with microbes from the mother’s birth canal. Babies that are born by cesarean section first encounter microbes from the mother’s skin and from other individuals who touch the baby. We don’t yet know whether the mode of birth has a permanent effect on the composition of one’s adult microbiome, but early results suggest that the effects can be long-lasting. The next source of microbes is breast milk. Surprised? Most of us are used to thinking of microbes as dangerous, so finding out that mother’s milk contains bacteria may be shocking. But in fact the microbes in milk play an important and very interesting role in the establishment of the baby’s healthy microbiome (see box on breast milk).

Newborns also acquire microbes from their fathers, siblings, and caregivers. As babies grow more mobile and begin to explore the world, they encounter both environmental microbes (like those that live in soil and water), and microbes that have been shed by other people, pets, and plants. They also ingest microbes in food as their diet becomes more diverse. The vast majority of environmental microbes will not become part of the microbiome; they are not capable of living in the habitats provided by the human body. Newly encountered microbes that can live in humans have to compete with the microbes that are already established in and on the infant. An important concept to remember is that of “selection” — as the human microbiome becomes established, there is selection going on in multiple directions; newly encountered microbes seek an appropriate environment, which includes both the conditions at the human body site, and the microbes that are already there. At the same time, the human is selecting for microbes that provide needed services and do not cause harm. Microbes sense and interact with specific markers that are secreted by cells or found on their surfaces and use these cues to “decide” where to grow. Thus, there is a role for human genetics in the eventual structure of the microbiome. The exact mechanisms that govern these selection processes are also under active study, but they certainly include a great deal of chemical communication, as well as physical cues like temperature and moisture levels. In any event, the set of microbes that end up constituting a mature microbiome is far from random — during the first two years of life, there is a process of mutual selection between the baby and the microbes it encounters.

Yes and no.

Each individual’s microbiome carries out many similar functions, but the jobs are not necessarily done by the same microbial species in each person. Also, the species carrying out the various functions in any given individual may change over time. The situation is analogous to any other kind of ecosystem — if you were to compare forests from all over the world, you would find trees, ground cover, birds, insects, and animals in each forest. Some might be dominated by oak trees, others by spruce, but the various ecological niches that make up a forest would all be filled. Another useful analogy is that of a city: every city has firefighters, police officers, bus drivers, and garbage collectors, but different people fill those roles in each city. In the human microbiome, certain broad functional capabilities are always found, but they are not always carried out by the same microbial species. Some functions are quite specific — for example, the ability to metabolize a particular drug or digest a specific dietary compound — and these functions are not found in everybody, or at all times.

The first five years of the Human Microbiome Project, a research program funded by the National Institutes of Health, examined the microbiomes of 242 healthy individuals at 15 (male) to 18 (female) body sites and found them to be quite diverse, both from individual to individual and from body site to body site. What did they find out?

• There is quite a bit of variation from one person to the next, but one’s own microbiome is fairly stable over time.
• The microbiomes of various body sites are similar in everyone. Thus, your skin microbiome is more similar to other people’s skin microbiomes than to your own gut microbiome.
• When microbiomes are classified by the bacterial species they contain, they look very different from person to person. If they’re classified by the presence of various functional capabilities — the ability to digest different kinds of carbohydrates, synthesize vitamins, or break down toxins, for example — they look more similar from person to person.

The Human Microbiome Project focused on healthy individuals with the goal of establishing a baseline description of a “normal” microbiome. Ongoing studies are starting to look at whether particular microbiome compositions correlate with particular diseases, disease risks, and responses to drugs or other treatments. Furthermore, microbiome studies are moving beyond identification of “who’s there” — that is, microbial species composition of the microbiome — to “what are they doing?” — that is, understanding their functions.

The microbiome definitely changes dramatically between birth and the age of about two years, when it begins to look like a typical adult microbiome. The situation is not unlike what happens after a fire or volcanic eruption in a natural environment; certain plants and animals are predictably the first to colonize the cleared area, with others arriving as the conditions change. After some years, the cleared area will resemble areas around it that were not disturbed.

It is worth noting that this natural succession of species may proceed differently in an area where there has been a lot of human activity. In such a situation, weeds, pests, or other invasive species may arrive first and out-compete the native plants. The area may never regain the native mix of species.

During the first two years of life, infants gradually acquire a microbiome that resembles the typical adult microbiome. Soon after birth is a unique time when, for example, rare microbes can become established — later they would be out-competed. The recognition that these early years are a crucial time for the establishment of the microbiome has drawn new attention to practices that are fairly recent human introductions — caesarean delivery, formula feeding, and, especially, the use of antibiotics early in life. The long-term impact of different practices on the microbiome is unknown. Indeed, it appears that the process of acquiring a functional microbiome is quite robust as the vast majority of babies, whether born vaginally or by cesarean, breastfed or not, do just fine. Nevertheless, long-term and detailed surveys will be required to determine whether such recent healthcare and nutritional practices have unintended consequences that are predictable, and possibly preventable.

After the adult-like microbiome is established, does it change over time, or can it be intentionally changed? On the simplest level, the answer to both questions is yes. The microbiome can change as a result of changing diet, treatment with antibiotics, or a move to a new environment, whether these changes are intentionally aimed at changing the microbiome or not.

The microbiome can change in different ways — some species will be found at all times while others will come and go. Certainly, the proportion of different species or groups of species will change. Characteristic distributions of certain groups of gut bacteria correlate closely with obesity and the microbiomes of individuals who lose weight will gradually come to resemble the microbiomes more characteristic of lean people. What is harder to measure, but certainly also true, is that the function of the microbiome can change even if its composition does not. This is because the microbes that make up the microbiome are complex organisms with diverse genetic capabilities. When conditions change, they will activate different metabolic pathways. That, in turn, will affect the microbes around them, and the human host.

Understanding how the microbiome can change over time requires getting into the mindset of an ecologist. Together a human host and its microbiome form an ecosystem — actually, many interacting ecosystems. Changes in any one member, or in the external environment, ripple through the community in ways that scientists are only beginning to unravel. The ultimate goal is to understand what constitutes a healthy human-microbiome ecosystem and then to develop the means to keep it healthy and repair it when necessary.

Any suggestion that complex conditions like diabetes or obesity can be explained simply by the composition of the microbiome is likely to be misleading. There have been many studies that show a correlation between certain mixtures of microbes and certain disease states, but evidence that any particular microbial community actually causes a particular disease is still limited. What is clear, however, is that the microbiome is probably an important factor in many diseases, a factor that has been neglected in the past. A better understanding of the microbiome will deepen our perception of human health and likely contribute to new kinds of treatments and more effective ways to deploy traditional treatments.

The early history of microbiology was dominated by the quest to identify the microbes responsible for disease, and find ways to stop them. As far back as 1890, the microbiologist Robert Koch and colleagues advanced the then-revolutionary idea that particular microbes caused particular diseases. The implications of this insight were profound. Identification and study of causative agents was the first step in developing ways to prevent and cure infectious diseases, certainly one of the public health triumphs of the 20th century.

Koch developed a set of postulates laying out the conditions that had to be fulfilled in order for a disease to be attributed to a particular microbe. Still used today, Koch’s postulates rest on the assumptions that each disease can be attributed to a particular microbe and that disease-causing microbes are not found in healthy individuals. The “one microbe-one disease” concept is so strong that many diseases are actually named for the microbe that causes them — for example, polio is caused by the polio virus and strep throat by the bacterium Streptococcus.

• Koch’s postulate #1:
  The microorganism must be found in abundance in all organisms suffering from the disease, but should not be found in healthy organisms.
• Koch’s postulate #2:
  The microorganism must be isolated from a diseased organism and grown in pure culture.
• Koch’s postulate #3:
  The cultured microorganism should cause disease when introduced into a healthy organism.
• Koch’s postulate #4:
  The microorganism must be re-isolated from the inoculated, diseased experimental host and identified as being identical to the original specific causative agent.

If you read Koch’s postulates with an awareness of the magnitude and multiple roles of the microbiome, you can see that their ability to describe the relationship between microbes and disease has become less universal. What is becoming clear is that not all microbially-associated diseases are “infectious” in the traditional sense. Some diseases are caused by microbes that are normal constituents of the microbiome, so they are found in both healthy and diseased individuals. E. coli, yeast, Staphylococcus aureus, and Clostridium difficile are all examples of potential pathogens that can be found in healthy individuals, but cause disease only when the microbiome is disturbed or the microbes gain access to a part of the body where they do not normally live. The role of the microbiome in crowding out or otherwise inhibiting pathogens is another reason that mere presence of a pathogen does not necessarily mean disease. A pathogen may not cause disease if it is introduced in the context of a healthy microbiome, or, conversely, a dramatically smaller dose of the pathogen may result in disease if the microbiome is disturbed. For example, the infectious dose of Salmonella is one-thousand fold lower for individuals who are on antibiotics.

Some diseases may be the result of disturbance of the microbial “community” that makes up the microbiome. In this case, the symptoms are not caused by a particular microbe, but by altered proportions of various normal constituents or altered behaviors of the normal constituents under conditions of stress. For example, the discomfort that many people experience after taking broad-spectrum antibiotics is the result of a disturbance of the normal microbial community in the gut that leads to gastrointestinal inflammation and diarrhea, and sometimes sets the stage for infections by pathogens like Clostridium difficile.

A corollary of the fact that human health depends on maintaining a good relationship with a complex set of microbes is the recognition that microbes can contribute to disease in previously unexpected ways. Many human diseases in which microbes were not previously thought to play a role have recently been shown, largely in animal models, to be at least partially influenced by the microbiome. Diseases as different as asthma, diabetes, obesity, cancer, and heart disease have been shown to be influenced by the microbiome. In mice, there are even intriguing, if very preliminary, indications that the microbiome may play a role in conditions like anxiety and insomnia.

The gut microbiome is not the only one with a role in disease and health; the microbiomes of the mouth, skin, vagina, lungs, and stomach are also altered in various disease states. The microbes in these body sites are not simply passive bystanders but are playing active roles in the dynamic balance between health and disease. In the majority of cases, the underlying mechanisms by which the microbiome affects health have not yet been determined, but highly suggestive correlations have been found. Research on model organisms, especially mice, is ongoing in an attempt to better understand exactly what is going on.

Complicating the effort to understand the role of the microbiome in many non-infectious diseases is the fact that most such conditions are multifactorial. Changes in the microbiome may be a major contributor in some patients or under certain conditions, but not all. Obesity, for example, has genetic, environmental, hormonal, neurological and many other contributing factors, in addition to the role of the microbiome.

Nevertheless, obesity is a disease in which the study of the microbiome could have profound implications for human health. Much of what scientists know, or suspect, about the roles of the human microbiome in metabolism come from studies in mice. Many experiments can be done with mice that would be impossible or unethical to impose on humans. For example, mice can be raised without a microbiome (such mice are called “germ-free”); microbes can be introduced in a defined manner (these mice are called “gnotobiotic” to signify that the composition of their microbiomes is precisely known); microbiomes can be swapped between mice; and diet can be completely controlled. Studies in mice suggest that there are very strong feedback loops connecting diet, the microbiome, and metabolism. Among the results that point to important roles for the microbiome in obesity and other metabolic conditions are:

• Mice that are maintained in the germ-free state are leaner than mice with microbiomes even when they are fed more food or a high-fat, high-sugar diet. Without a microbiome, much of the food passes through undigested.
• Germ-free mice that are inoculated with the microbiome of an obese mouse or human donor gain more fat than those that receive the microbiome of a lean control, even when both receive the same amount of food. Co-housing these two groups of mice allows bacteria from the lean donor to invade the obesity-associated gut microbiome, blocking the increase in body fat.
• Microbiome composition changes within a single day when mice or humans are fed high-fat diets. When the resultant “high-fat” microbiome is transferred into a germ-free mouse, that mouse will be fatter than a littermate given the microbiome of an adult on a normal diet.

These and many other observations in mice, humans, and other animals suggest not only that the microbiome has a major effect on body fat, but that it is possible to shift the microbiome in ways that either encourage or discourage the accumulation of fat. It should be noted, however, that at this point, most studies, even in mice, are looking at correlations between gut microbiome composition and factors like weight, insulin sensitivity, and other metabolic measures. And, of course, while mice are excellent model organisms for understanding human health, they are not perfect and it is not clear how the human and mouse microbiomes will differ in their effects on the host’s health and metabolism. Exactly how the microbiome exerts these effects is the subject of intense study as is the question of whether the composition of the human microbiome can easily be shifted from one state to another. The prospects, however, are intriguing.

In addition to obesity, studies examining the gut microbiome in humans have found a number of interesting correlations between microbiome composition and several diseases related to inflammation of the gut including inflammatory bowel and Crohn’s diseases. Disorders related to auto-immune reactions, including celiac disease, asthma, and other allergies have also been related to differences in microbiomes, or correlated to factors that affect microbiome composition like vaginal vs. cesarean section birth, or extent of antibiotic exposure. Disruption of the gut microbiome by antibiotics has been implicated in the development of persistent Clostridium difficile infections, but not everyone who takes high dose antibiotics develops this condition. A great deal of work remains to be done to determine the role that particular microbes or combinations of microbes play in any or all of these conditions. The answers are likely to be complicated because the microbiome does not exist in a vacuum and no two human microbiomes are the same. There is a dynamic relationship between the microbiome and many other factors. One’s individual genetic make-up may affect which microbes your body will encourage, tolerate, or reject. Major changes in diet do not only affect the microbiome — they affect the host as well, setting up a complex web of feedback interactions. Environmental factors like exposure to antibiotics and other drugs, or moving to a new geographic location, may also change or even destabilize the microbiome.

Now that you know about the trillions of microbes that call you home, and play such an important role in health, you may be wondering what you can do to keep them happy. The answer, for the moment, is that we just don’t yet know what characterizes a healthy microbiome, or how our behavior affects it. There are a few things we can say, though. Broad-spectrum antibiotics can have a profound and often long-lasting effect on the microbiome. They can also be life-savers. The key is to use antibiotics only when necessary.

We also know for certain that your diet can affect your microbiome in two ways. First, just as we say that a pregnant woman is eating for two, it is absolutely true that you are eating for yourself and trillions of microbes. The foods you consume are also feeding your microbes. Some foods encourage the growth of microbes that are associated with good health — these foods contain certain compounds, like specific carbohydrates, that “feed” desirable microbes. The compounds are called “prebiotics.” Thus, one of the ways that a diet rich in fiber, fruits, and vegetables contributes to good health is that it also encourages a healthy microbiome. Second, consuming microbes can change your GI microbiota. Fermented foods like yogurt, cheese, and sauerkraut actually contain microbes that are similar to those found in your GI tract. There are also supplements that are made up solely of microbes, called “probiotics.” There is lots of evidence that probiotics can contribute to health, but caution is called for. Probiotics are not regulated like drugs, so labels may not accurately reflect which microbes are present, whether they are viable, or how many are in a serving. For many prebiotics and probiotics, the kind of rigorous clinical testing that establishes whether a drug is effective, how much is needed, and how often it should be taken has not been performed. Measuring health and testing health claims can be a challenge given that medical knowledge about what defines “healthy” pales in comparison to what is known about disease. Probiotics are sometimes marketed as undifferentiated “cure-alls,” as if any microbe or mixture of microbes will be helpful for any condition. But probiotics are probably more analogous to any other kind of therapeutics, like drugs. After all, you don’t just take a random drug if you are ill; you seek out the right drug for that disease or symptom. Over time, clinical testing will reveal which probiotics are effective for which conditions, in which patients. Indeed, some specific mixtures of microbes have already demonstrated effectiveness in treating irritable bowel syndrome and ulcerative colitis in randomized clinical trials.

As scientists and physicians learn more about the microbiome, the activities of pre- and probiotics will be better understood and it will be possible to apply more rigorous standards. Then it will be possible to give the public better guidance on how best to care for their microbiomes. Study of the human microbiome is a rapidly advancing field of science with new and exciting discoveries emerging constantly. You can be sure that you’ll be hearing more and more about the essential microbial partners that make up your microbiome.

Wherever the human body is exposed to the outside world, there is a microbial community. That means that the entire surface of the skin, and the linings of the nasal passages, lungs, digestive and urogenital tracts are all home to microbial communities. Some of these communities are extremely dense and others more sparse. And because the living conditions are very different in these different sites, it is no surprise that each one has its own characteristic set of microbes. What the microbiome is doing also varies from place to place and many of its functions have not yet been worked out. Here are some examples of human microbiome communities:

Skin

Microbes live on all skin surfaces as well as within pores and sweat glands, and along hair shafts. The composition of the skin microbiome varies from place to place, with dry areas like the arms and legs having fewer and different microbes than moist or oily areas like the armpits or nasal creases. There are indications that some commonly found skin microbes can help keep away pathogens. For example, the frequently found Staphylococcus epidermidis has been shown to produce compounds that inhibit the related, but pathogenic, Staphylococcus aureus.

Mouth

About 1000 microbial species have been found in the human mouth, with any individual person usually hosting 100-200 species. Like the skin, the mouth contains many different microhabitats including tooth surfaces, tongue, cheeks, and gums. Most of these habitats are exposed to the air, but the pockets formed where teeth emerge from the gums can be anaerobic and permit the growth of microbes that can grow without oxygen. In what is emerging as a common theme when it comes to the human microbiome, the line between oral health and diseases like dental caries (cavities) and periodontal (gum) disease seems to depend on maintaining a well-functioning community of microbes that exists in harmony with the immune system. When this balance is disrupted, pathogens can gain a foothold.

Gut

The gut is the best-studied site in the human microbiome and it contains the largest, densest, and most diverse microbial community in the human body. In fact, the microbial community in the human large intestine, at up to 100 billion to one trillion cells per milliliter, is among the densest microbial ecosystems ever observed. The gut microbiome acts as a highly efficient bioreactor, helping to extract energy and nutrients from the food we eat. Like the microbial communities elsewhere on the body, the gut microbiome protects against pathogens and is in constant communication with the immune system.

The gut microbiome is also important because of the many chemical reactions that can be carried out by microbes. Compounds that humans cannot digest on their own can be broken down by microbes. Evolutionarily, these microbial capabilities allowed humans to benefit from a wider variety of foodstuffs. The metabolic diversity of microbes also has a contemporary impact. Gut microbes have been found to affect the metabolism of some drugs, such as digoxin (a heart medication often used to treat atrial fibrillation) and acetaminophen (used to treat pain and fever). A drug used to treat advanced colorectal cancer, called irinotecan, or CPT-11, which is normally detoxified by the liver, is turned back into its active form by gut microbes, causing extensive cell death in the intestines and thus severe diarrhea. Prescribing an additional drug that inhibits the microbial enzyme responsible for re-activation may allow cancer patients to be given higher doses of the anticancer drug.

Finally, the gut microbiome has complex effects on human metabolism and changes in its composition have been linked to a number of diseases including inflammatory bowel disease, Clostridium difficile infections, autoimmune disorders, and even diabetes and obesity. In most cases, the associations between the microbiome and these diseases are just that — associations. Many specific mechanisms have been demonstrated in animal models, but it is not yet known which are most important in humans. What is certain is that the microbes of the gut are extremely metabolically active in their own right and many of the chemical compounds they secrete — known as metabolites — pass through the gut wall into the bloodstream and circulate throughout the body. There are intriguing indications that the gut microbiome may affect sleep patterns, mood, and other behaviors. Again, the science is still young, but it is clear that the microbiome has many systemic effects.